IL2 and neoplasm: Others have described modulation of cytokine production of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17A, TNF-α, and IFN-γ on tumor cells treated with conventional PDT [36,37,38], but their increase or decrease seems to highly depend on the cell line and PDT protocol used.