PAFAH2 and endothelial dysfunction: Notably, overexpression of platelet-activating factor acetyl hydrolase 2 (PAFAH2), an enzyme specifically hydrolyzing truncated OxPLs, rescued cytokine-induced endothelial dysfunction while pharmacological inhibition of PAFAH2 exacerbated cytokine-mediated inflammation in EC cultures and in mice lungs [52,126].