MFN2 and Charcot-Marie-Tooth disease: We will briefly review here the pathophysiological role of two of the most common causative genes for axonal CMT2, mitofusin 2 (MFN2) and ganglioside induced differentiation-associated protein 1 (GDAP1), where oxidative stress takes place when these proteins are mutated (Figure 3), but not all the other types of CMT where oxidative stress has not been demonstrated.