A second autochthonous case in Leipzig, an 81-year old male, was admitted to the ICU with presumptive diagnosis of pneumonia, then transferred to the ID-ICU and was found to have WNND confirmed by WNV IgM and IgG in serum samples as well as WNV RNA in CSF samples as early as from 19 September. This evidence concerns the gene CD40LG and susceptibility to pneumonia measurement.