As a matter of fact, the last version of the National Comprehensive Cancer Network (NccN) Guidelines has sharply separated treatment pathways for p16-positive and p16-negative oropharyngeal carcinomas, but the treatment options for p16-positive and p16-negative oropharyngeal carcinomas are almost identical, with the below-mentioned differences only. This evidence concerns the gene CDKN2A and oropharyngeal carcinoma.