CYLD and head and neck squamous cell carcinoma: TRAF3 and CYLD gene deletions or disruptive mutations were identified in 28% of HPV-positive specimens in the initial TCGA HNSCC cohort and it correlated to the absence of HPV gene integration and decreased tobacco exposure [59], leading to the consideration that both DNA damage and the presence of reactive oxygen species (induced by tobacco mutagens) may favor HPV integration.