As for sEV cargo characterization, protein levels of adenosine triphosphate 5A (ATP5A; complex V), nicotinamide adenine dinucleotide reduced form (NADH):ubiquinone oxidoreductase subunit S3 (NDUFS3; complex I), and succinate dehydrogenase complex iron sulfur subunit B (SDHB; complex II) were lower in participants with PF&S than in non-PF&S controls (Figure 4A–C). Here, NDUFS3 is linked to pemphigus foliaceus.