TNC and osteosarcoma: Interestingly, while in osteosarcoma, TNC binding to α9β1 integrin promoted metastasis by repressing YAP nuclear translocation and target gene activation [214], TNC binding to α5β1 integrin in Ewing sarcoma promoted metastasis by activating YAP [207], potentially through activating tyrosine phosphorylation by SRC kinase [213].