SERPINF1 and osteosarcoma: For example, pigment epithelium-derived factor (PEDF), which is frequently low in tumors and whose overexpression reduced orthotopic growth and metastasis in osteosarcoma [176], induced a decrease in p-AKT, p-ERK, p-FAK, RHOA and CDC42 protein levels in chondrosarcoma cells associated with decreased adhesion and invasion [177].