WWTR1 and neoplasm: YAP and TAZ act as the ultimate nuclear effectors of signals transmitted from intrinsic biochemical and extrinsic biomechanical cues resulting from changes in the microenvironment and the architecture of tissues, including extracellular matrix rigidity, cell-cell and cell-matrix adhesion, cell density, shape and polarity, all of which play a role in metastatic dissemination and the homing of tumor cells to distant sites.