Since RAC was shown to activate YAP in response to β-integrin signaling in MSC [63] and CXCR4 was reported to activate YAP in other cancers (i.e., non-small cell lung cancer [226]), it is possible that the metastatic spread of Ewing sarcoma cells with high CXCR4 may be supported by a mechanism involving YAP/TAZ. This evidence concerns the gene YAP1 and Ewing sarcoma.