A recent study of Gan et al. showed that genistein can inhibit isoproterenol-induced cardiac hypertrophy by increasing miR-451 and the tissue inhibitor of metalloproteinases 2 (TIMP2) expression (a miR-451 target gene), both in vitro in H9C2 embryonic rat cardiomyocytes and in vivo in isoproterenol-induced myocardial hypertrophy in mice [270]. The gene discussed is TIMP2; the disease is cardiac hypertrophy.