In a recent in vivo study, Wang et al. demonstrated that administration of 6-gingerol to fat-fed apoE-deficient mice determines the reduction of atherosclerosis, expressed as decreased plaque formation and reduced levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) by a mechanism mediated in part by AMPK activation [302]. The gene discussed is IL1B; the disease is atherosclerosis.