Regarding the role of galectin-3 in CRF07_BC infection, our data indicated that a higher concentration of galectin-3 was detected in the plasma of patients with CRF07_BC infection, CRF07_BC infection upregulated the expression of galectin-3, and the amino acid deletions in CRF07_BC p6Gag ameliorated the galectin-3 regulatory effects. This evidence concerns the gene LGALS3 and infection.