DNMT3A and acute myeloid leukemia: An analogous scenario is established in the development of acute myeloid leukemia, which is often preceded by clonal hematopoiesis elicited by mutations in various genes, most often encoding epigenetic regulators like DNMT3A and TET2 [35], which shift the balance between stem cells and differentiated progeny and displace normal with stem cells with mutants.