Furthermore, in some AML cell lines and primary cells, both p70S6K and 4EBP1/eIF4E signaling pathways are influenced by manipulations in SYK activity, and combined chemical inhibition of SYK and eIF4E has shown a synergistic effect on AML viability in multiple AML cell lines [109]. The gene discussed is RPS6KB1; the disease is acute myeloid leukemia.