According to the findings by Schoergenhofer et al. [17] and Thomas et al. [48], P2Y12 inhibition reduced systemic inflammation but not platelet-neutrophil aggregation and NET markers in humans given a single bolus of endotoxin; a possible NET-dependent miR-150 release could explain why this miRNA is such a robust marker of endotoxemia but is not affected by the anti-inflammatory effects of P2Y12 inhibitors. This evidence concerns the gene P2RY12 and serum lipopolysaccharide activity.