Likewise, MetS was associated with an up-regulation in the gene expression of IL-6, MCP-1, TGF-β, LO, GSR, and iNOS in myocardial tissue (Figure 8F; p < 0.05 for all) that was significantly attenuated by CSAT+® supplementation (Figure 8F; p < 0.05 for all). The gene discussed is NOS2; the disease is metabolic syndrome.