On the contrary, endothelium-dependent relaxation in response to Ach was significantly decreased in aorta segments from untreated mice with MetS (Figure 5C; p < 0.001), an effect that was prevented by CSAT+® supplementation (p < 0.05), and by incubation of aorta segments with the antioxidants Tempol and Catalase (Figure 5D; p < 0.05). This evidence concerns the gene CAT and metabolic syndrome.