AKT1 and Insulin resistance: In our model, the beneficial effect on the glycemic status seems to be mediated by a reduction in MetS-induced insulin resistance in skeletal muscle and visceral adipose tissue, since we found a significant activation of the PI3K/Akt pathway in response to insulin in both visceral adipose tissue and gastrocnemius muscle explants from chow and CSAT+® -treated mice but not in explants from mice fed with the HFHS diet alone.