RETN and Insulin resistance: Lee et al. reported that IQ suppressed the adipogenesis in 3T3-L1 cells via the inhibition of Wnt/β-catenin signaling, regulation of lipid metabolism-related factors such as PPARγ, C/EBPα, SREBP-1, adiponectin, resistin, visfatin, and improvement of insulin resistance [54,56].