They can also transcriptionally regulate nearby genes, as in the case of ANRIL, the expression of which correlates positively with the master tumor suppressors p14-ARF and p15-CDKN2B in normal tissues, and much more positively and statistically significantly with p14-ARF, p16-CDKN2A and p15-CDKN2B in tumor tissues [140]. The gene discussed is CDKN2B; the disease is neoplasm.