MSN and cancer: In a further network analysis with protein–protein interactions, we confirmed a tight clustering of MSN with several key proteins, including ITGA6, ITGB4, FERMT3, FLNA, LCP1, CORO1A, FMNL1, ARHGEF2, and MMP9, all of which modulate membrane ruffling, lamellipodia and filopodia formation, cell–ECM interaction, and ECM remodeling that play a crucial role in cancer cell invasion [48] (Figure S6).