MAP2K1 and neoplasm: Several key proteins such as MAP2K1 [38], ITGB4 [39], ITGA6 [40], PTPN6 [41], FMNL1 [42], ANXA1 [43], and MMP9 [44] that modulate cell motility and tumor cell invasion were upregulated in MIBUC (Figure 1B, Table S3).