However, we observed the absence of total cytotoxic activity suppression against autologous tumor cells due to the impaired mTNFα expression, as evidenced by the expression of other mediators (perforin, granzyme B, FasL and TRAIL) in glioblastoma patient-derived IFN-DCs cultures was preserved at the levels comparable with that of donor IFN-DCs. This evidence concerns the gene PRF1 and glioblastoma.