Mantle cell lymphoma (MCL) is characterized by its genetic hallmark, the chromosomal translocation t(11;14), which results in increased expression of cyclin D1 in B cells, alterations in the DNA damage response, and constitutive activation of key anti-apoptotic pathways, such as phosphatidyl-inositol 3-kinase (PI3K)/Akt and nuclear factor-kB (NF-kB) [1]. The gene discussed is CCND1; the disease is mantle cell lymphoma.