A swimming training program of 90 min per day, 5 days a week performed for 8 weeks proved to be effective in attenuating myocardial fibrosis and contractile dysfunction [148], reduced cardiac glycogen storage [149] and level of tumor necrosis factor-α (TNF-α), and increased capillary density [150] in Wistar rats with streptozotocin-induced DM. This evidence concerns the gene TNF and Myocardial fibrosis.