Pan-cancer analysis, including the integrative altered methylation studies on DNMT3B methylation patterns, revealed key metabolic genes, such as solute carrier family 2 member 1 (SLC2A1), ATP citrate synthase (ACLY) and lysine acetyltransferase 2A (KAT2A), as commonly contributing factors to errors of histone modifications and DNA methylation [103]. This evidence concerns the gene ACLY and cancer.