SPON2, which is the secreting-type ECM Spondin 2 (SPON2, formerly Mindin, DIL-1), a member of the Mindin F-Spondin family, is highly expressed in many tumors but its molecular mechanisms and implication in cancer remains unclear although high levels of expression are correlated with a poor prognosis, migration, and proliferation [38]. This evidence concerns the gene SPON2 and cancer.