CCND1 and intestinal neoplasm: A study of intestinal tumors isolated from mice carrying an intestinal-specific conditional knockout of Cftr alone (Apc wildtype) found enhanced nuclear localization of β-catenin, an indicator of activation, along with elevated expression of Wnt/β-catenin target genes such as Cyclin d1 (Ccnd1), Lgr5, and cluster of differentiation 44 (CD44) [5].