Thus, the whole sample significantly decreased their CRP (Δ = −1.4 mg/L) concentrations (i.e., inflammatory marker associated with cardiovascular disease) which could be explained by multiple mechanisms, including a decrease in cytokine production by adipose tissue, skeletal muscles, endothelial and blood mononuclear cells, improved insulin sensitivity and endothelial function, and possibly an antioxidant effect [34]. This evidence concerns the gene INS and cardiovascular disorder.