The present study showed that the MUO profile in the EXERDIET-HTA group (i.e., obesity, HTN, fasting glucose > 100 mg/dL, LDL-C > 100 mg/dL, TC > 200 mg/dL, ALT > 30 U/L, systemic inflammation with CRP > 3 mg/L, and low CRF, 22.4 ± 5.4 mL·kg−1·min−1, Figure 2) was significantly worse than the HEALTHY non-obese group (Table 1). The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.