Based on findings from the current study and that previously presented by the research team [11,14], the 16-week intervention was effective in changing the metabolic profile from MUO to MHO according to the following criteria (Figure 2) [7]: from obesity to overweight lowering body fat, with TC, ALT, glucose, and CRP moving from unhealthy to optimal cut-off values, reflecting the absence of metabolic abnormalities and lower levels of systemic inflammatory mediators, and CRF from “percentile under 50” to “percentile upper 50” for V·O2peak classification [29]. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.