VEGFA and hepatocellular carcinoma: Polymorphisms in other genes directly related to the VEGF-dependent angiogenesis pathway, such as c.-813C>T (g.150992991C>T, rs2070744) in eNOS3, c.714G>T (p.Thr238Thr, rs55633437) in ANGPT2 and c.1065+2924G>A (g.61730580G>A, rs12434438) in HIF1A have also been linked to sorafenib efficacy in HCC patients [131,154].