TP53 and acute leukemia: Also in 2010, Andreef and co-workers reported that JNJ-26854165 was able to induce p53-mediated apoptosis in acute leukemia cells, as well as S-phase delay and E2F1-mediated apoptosis in p53 mutant cells, acting along with 1-β-arabinofuranosyl-cytosine or doxorubicin in order to cause p53-mediated apoptosis [146].