These results suggest that ginsenosides and their metabolites can alleviate asthma, allergic rhinitis, AD, and scratching behavior by inhibiting IgE and IL-4 expression, NF-κB activation, and Ca2+ influx; increasing IFNγ expression; and stabilizing the degranulation of mast cells and basophils. The gene discussed is NFKB1; the disease is Alzheimer disease.