One of the growth factors secreted by TAMs is the epidermal growth factor (EGF), which stimulates the expression of its receptor (EGFR) in breast cancer cells to continuously activate the signal transducer and activator of transcription 3 (STAT3)/SRY-Box Transcription Factor 2 (Sox-2) signaling pathway enhancing cancer cell survival and proliferation in mice [48,49,50]. The gene discussed is SOX2; the disease is cancer.