Recently, it was demonstrated that Tregs inhibit the production of IFN-γ by CD8+ T cells and increase sterol regulatory element-binding protein 1 (SREBP1)-dependent lipid metabolism in TAMs to promote the immunosuppressive M2-like TAM phenotype in B16 melanoma and MC38 colon adenocarcinoma tumor models [138]. The gene discussed is CD8A; the disease is neoplasm.