A recent study demonstrated that efferocytosis of apoptotic cancer cells activates NF-κB and STAT3 transcriptional machinery to promote the production of the pro-inflammatory C-X-C motif chemokine 5 (CXCL5) in the bone microenvironment, which supported prostate cancer skeletal metastasis [44]. The gene discussed is CXCL5; the disease is prostate carcinoma.