In addition, using RNAsope analyses of 3 differently-staged HCC cases from the Taipei Medical University-Shuang-Ho Hospital patients cohort (n = 72), we showed that in contrast to the lack of MALAT1 expression in adjacent non-tumor tissues, MALAT1-positive cells were widely distributed in HCC tissues, and per intensity, MALAT1 was strongly, moderately or mildly expressed in Stage III/IV (n = 42), II (n = 18) or I (n = 12) HCC tissues, respectively (Figure 2B and Supplementary Figure S2). The gene discussed is MALAT1; the disease is neoplasm.