This is consistent with findings indicating that the siRNA-mediated genetic ablation or antisense oligonucleotides (ASOs)-mediated systemic silencing of MALAT1 in the mouse mammary tumor virus (MMTV) - polyoma middle tumor-antigen (PyMT) mice breast cancer models concomitantly attenuated tumor growth and elicited significant differentiation into cystic tumors, enhanced cell adhesion, with reduced migration and metastasis [24]. Here, MALAT1 is linked to cystic neoplasm.