Furthermore, using the RNAscope staining assay, we demonstrated for the first time to the best of our knowledge, that compared to the non-tumor liver tissue with no expression of MALAT1 or liver cirrhosis and well-differentiated HCC tissues with mild expression of MALAT1, the moderately-to-poorly-differentiated HCC exhibited strong and well-distributed expression of MALAT1 (Figure 2D). Here, MALAT1 is linked to neoplasm.