In the study of Øystese et al., the authors also found that in male gonadotroph tumor patients only, a negative IRS of ERα (0 or 1) was associated with a higher reintervention rate and with an earlier reintervention and that the absence of ERα together with a younger age predicted the need for reintervention in male patients [9]. The gene discussed is ESR1; the disease is neoplasm.