However, IRS ERα was higher (mean = 2.4, SD = 2.6) in the “absence of tumor growth” group compared to “tumor growth” group (mean = 1.5, SD = 2), and at the same time, in the “tumor growth” group, no tumor out of 15 presented a % of ERα+ cells of ≥10%, in comparison to 3 out of 19 tumors in the “no change” group and 5 out of 19 tumors in the “shrinkage” group. This evidence concerns the gene ESR1 and neoplasm.