In the future, treatment options for this group may potentially include combinations between ER-targeted therapy, including selective estrogen receptor modulators (SERMs), SSTs ligands and/or D2R agonists, like for example combinations of SERMs + SSTs ligands as recently tested in acromegaly [33] or chimeric molecules like TBR-760, a dopamine-somatostatin chimeric molecule, which is expected to enter soon into a Phase 2 clinical trial in patients with NF-PitNETs [34]. Here, ESR1 is linked to acromegaly.