Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by synovial proliferation and inflammatory responses, the presence of autoantibodies including rheumatoid factor and anti-citrullinated protein antibodies (ACPA) in sera, cartilage, and bone erosion with deformity, and co-occurring health conditions such as cardiovascular disease events, pulmonary, psychological, and metabolic bone disorders [1]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.