Furthermore, specific target analysis carried out in ovarian cancer cell lines revealed that ACO2 transcript is a potential direct target for miR-450a, which could explain the observed decrease in glutamate production and increase in glutamine consumption by miR-450a, since ACO2 converts citrate into isocitrate, regulating the Krebs cycle and glutaminolysis. The gene discussed is ACO2; the disease is ovarian carcinoma.