ACO2 and ovarian carcinoma: Interestingly, transcriptome analysis in A2780 ovarian cancer cells revealed that overexpression of miR-450a downregulated the genes involved in epithelial–mesenchymal transition (EMT), such as VIM, TWIST1 and SERPINE1. Genes related to mitochondrial metabolism were also downregulated, including ACO2, TIMMDC1, ATP5B and MT-ND2.