For example, pH-sensitive chitosan microgels containing large-pore silica particles loaded with GOx and cerium oxide nanoparticles (Ce-NPs, having an excellent antioxidant catalytic activity), can respond to hyperglycemia and self-regulate the release of insulin in vitro to mimic the repetitive change between hyper (400 mg mL−1) and normoglycemic (100 mg mL−1) state [74]. This evidence concerns the gene INS and Hyperglycemia.