For example, zebrafish melanoma models expressing the common melanoma oncogenes BRAFV600E, NRASQ61K and HRASG12V under the melanocyte-specific mitfa promoter, or HRASG12V under the kita promoter, are all sufficient to drive melanoma tumour formation, either alone or in combination with p53−/− mutation [21,22,23,24]. This evidence concerns the gene TP53 and melanoma.