IL-8 was expressed in zebrafish PNCs in response to oncogenic Ras expression [140,187] and IL-8 signalling through Cxcr1/2 chemokine receptors was shown to drive pro-tumour neutrophil recruitment at the pre-neoplastic stage in zebrafish models of skin and liver cancer, contributing to PNC proliferation and sustained tumour-promoting inflammation [68,104]. The gene discussed is CXCL8; the disease is liver cancer.