All three genes were under expressed in the spinal tissue from sporadic ALS patients compared to spinal tissue from healthy individuals (Figure 3, GAD2 logFC = −1.78, GABRE logFC = −1.39, CALB1 logFC = −1.96) and overexpressed in oculomotor tissue when compared to spinal tissue in neurologically normal patients (Figure 4, GAD2 logFC = 2.69, GABRE logFC = 2.34, CALB1 logFC = 2.45). This evidence concerns the gene CALB1 and amyotrophic lateral sclerosis.