TARDBP and amyotrophic lateral sclerosis: Mutations in several genes, including C9ORF72 (Chromosome 9 open reading frame 72; helps to regulate RNA transcription and translation), SOD1 (Super oxide dismutase 1; encodes superoxide dismutase, which helps to eliminate harmful reactive oxygen species), and TDP-43 (TAR DNA-binding protein 43; encodes a transcription factor) have been implicated in both forms of ALS [2,3,4].