AHR and neoplasm: Research conducted at sites of technological disasters or under unfavorable environmental conditions with dioxin emissions has shown that in one study (in Seveso, Italy), there were no significant changes in the incidence of pituitary adenoma [59], and in another (in Messine, Italy), there was an increased incidence of acromegaly as a result of a tumor, which was associated with AhR polymorphic variants rs2066853 and rs4986826 [60].