The AhR signaling cascade can interact with signal transduction pathways of other transcription factors, such as nuclear factor NF-κB, which regulates apoptosis, development, immune responses, and the stress response [28], and HIF-1α (a hypoxia-induced factor) which is involved in the regulation of immunity, circadian rhythms, and tumor progression [29,30,31]. This evidence concerns the gene AHR and neoplasm.