CERS5 and colorectal carcinoma: The protein content was lower in CRC tissue compared to normal intestinal tissues, for serine palmitoyltransferase (1.0 ± 0.10 vs. 0.43 ± 0.06; p = 0.0003), ceramide synthase 1 (1.0 ± 0.07 vs. 0.73 ± 0.06; p = 0.002), ceramide synthase 5 (1.0 ± 0.05 vs. 0.71 ± 0.05; p = 0.00007), and cytochrome C oxidase IV (1.0 ± 0.13 vs. 0.77 ± 0.09; p = 0.041) (Figure 1).