We present a case of a 38-year old male, who never smoked with disseminated <i>ALK</i>-rearranged (<i>EML4</i> (20) - <i>ALK</i> (20) fusion variant 2) lung adenocarcinoma, who received four sequentially different ALK-TKIs and two lines of chemotherapy in-between. This evidence concerns the gene ALK and lung adenocarcinoma.