Germline pathogenic variants in CDKN2A/ARF have been found in 20–45% of familial CM cases [1] and in 11–19% of multiple primary melanomas (MPM) [2] from the Italian population, characterized by a high prevalence of CDKN2A pathogenetic variants [3] often associated with pancreatic cancer (PC) and other cancers [4,5]. The gene discussed is CDKN2A; the disease is pachyonychia congenita.