Another minor limitation is that the panel did not include several rare/very rare recently proposed candidate melanoma genes such as GOLM1 (golgi membrane protein 1) [61], POLE (DNA polymerase epsilon, [62]), NEK11 [63], EBF3, OCA2, TYR, TYRP1, and SLC45A2 [26,59,64,65,66], reviewed in [67]. The gene discussed is POLE; the disease is melanoma.