Surprisingly, no correlation between p66Shc expression and TP53 defects has been observed in leukemic cells from either CLL patients or Eμ-TCL1/p66Shc−/− mice [52], notwithstanding a documented crosstalk between p53 and the ROS-elevating activity of p66Shc [49]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.