However, the invasion of tumor cells from peripheral blood is a complex process, during which tumor cells can undergo epithelial-to-mesenchymal transition (EMT) that involves the downregulation of epithelial markers, such as EpCAM, cytokeratins and E-cadherin, and the upregulation of mesenchymal markers, such as vimentin and N-cadherin. This evidence concerns the gene VIM and neoplasm.