All monoclonal abzymes against DNA and MBP showed different affinity for antigens, pH optima, dependence on various metal ions, etc. If take into account the average percentage of active monoclonal abzymes (~32–35%) in each of 10 eluted peaks containing abzymes, a possible number of monoclonal abzymes with DNase and MBP-hydrolyzing activity in total pool of SLE MLChs can be ≥1000 [40]. This evidence concerns the gene MBP and systemic lupus erythematosus.