MAPT and amyotrophic lateral sclerosis: For instance, a misfolded amyloid-β and mutated tau, α-synuclein, huntingtin, and ALS-linked trans-activation response (TAR) DNA-binding protein 43 (TARDBP) along with FUS are implicated in molecular mechanisms of Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis (ALS), respectively [7].