Besides, the chelate-coupled losartan-Leucine-Diglycoloyl-Tetraethyleneglycol-Tetraamine (Figure S10) showed superior AT1R affinity compared to parental losartan; radiolabeling of this compound with 99mTc displayed an acceptable biodistribution profile in mouse model of post-myocardial infarction heart failure [46]. The gene discussed is AGTR1; the disease is heart failure.