Among them, overexpression of USP11 was found in CHOL, colon adenocarcinoma (COAD), HNSC, liver hepatocellular carcinoma (LIHC), and pheochromocytoma and paraganglioma (PCPG), while under-expression was observed in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), Lung adenocarcinoma (LUAD), prostate adenocarcinoma (PRAD), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC). The gene discussed is USP11; the disease is colon adenocarcinoma.