Recently, liver-X nuclear receptor (LXR) activation by agonism RGX-104 has been shown to enhance the transcription of ApoE (genetic risk factor for Alzheimer’s disease), which combines with low density lipoprotein receptor-related protein 8 (LRP8) and induces the depletion of MDSCs [80]. This evidence concerns the gene LRP8 and early-onset autosomal dominant Alzheimer disease.