XBP1 and ulcerative colitis: Our group has also been performing these investigations over the past few years, and has touched on many aspects of several berberine-type alkaloids in pharmaceutical chemistry, such as studies on the structural modifications of quaternary coptisine chloride and quaternary palmatine chloride, the exploration of the pharmacological activities of X-box-binding protein 1 (XBP1), which include transcriptional activation, anti-ulcerative colitis, and antibacterial [18,19,20,21,22].