The potential clinical relevance is less pronounced, as just half of the studies reported associations between increased MMP2 or MMP9 levels with clinical characteristics such as survival, metastasis or tumor stage [43,46,47,48,50,51,53,56,57,58,61,63,65,67,68,72,73], whereas in the other half of the studies no such correlations were observed (Table 2). The gene discussed is MMP9; the disease is neoplasm.