With the findings of reduced miR‐483 level in circulation and PAECs of IPAH patients and that miR‐483 targeted several PAH‐related genes in cultured PAECs, we investigated whether a supraphysiological level of miR‐483 mitigates experimental PH in rat models by generating a transgenic rat line with miR‐483 expression driven by the VE‐cadherin promoter (i.e., EC‐miR‐483‐Tg). Here, CDH5 is linked to pulmonary arterial hypertension.