Compared with control rats receiving scramble RNA, the levels of miR‐483 in sera and lung were decreased, while the mRNA and protein levels of PAH‐related genes (e.g., TGF‐β, TGFBR2, β‐catenin, CTGF, IL‐1β, and ET‐1) were upregulated in rats having LNA‐483 (Appendix Fig S5A–C). This evidence concerns the gene IL1B and pulmonary arterial hypertension.