Previous studies have shown the controversial effects of Gas6/AXL in several kidney disease models, e.g., anti-Thy-1-induced nephritis, anti-glomerular basement membrane (GBM)-induced nephritis, streptozotocin-induced diabetic nephropathy, and renal ischemia-reperfusion [21–24, 34–37]. The gene discussed is GAS6; the disease is diabetic kidney disease.