Furthermore, the gene-enrichment analysis of 166 protein-coding genes from the THCA-EL-AUROC signature set revealed their significant enrichment in various KEGG pathways including the Focal adhesion pathway, PI3K-Akt signaling pathway, and Proteoglycans in cancer, etc. Notably, the Focal adhesion kinase has already been shown to be overexpressed in thyroid cancers [63]. This evidence concerns the gene AKT1 and cancer.